| Rothia mucilaginosa |
Taxonomy
Morphology
Cultural characteristics
Biochemical characters
Ecology
Pathogenicity
References
Phylum Actinomycetota, Class Actinomycetes, Order Micrococcales, Family Micrococcaceae, Genus Rothia, Rothia mucilaginosa
(Bergan and Kocur 1982) Collins et al. 2000.
Old synonyms: Stomatococcus mucilaginosus (ex Migula 1900) Bergan and Kocur 1982, "Micrococcus mucilaginosus” Migula 1900.
(Bergan and Kocur 1982) Collins et al. 2000.
Old synonyms: Stomatococcus mucilaginosus (ex Migula 1900) Bergan and Kocur 1982, "Micrococcus mucilaginosus” Migula 1900.
Gram-positive cocci, 0.9-1.3 µm in diameter, mostly variable in size and arranged in
clusters, occasionally in pairs and tetrads. Encapsulated. Non-acid fast. Non-motile.
Non-spore-forming.
clusters, occasionally in pairs and tetrads. Encapsulated. Non-acid fast. Non-motile.
Non-spore-forming.
Colonies on blood agar are transparent or whitish, have entire edges, mucoid with a
glistening, smooth, convex surface, and 1-1.5 mm in diameter. They are adherent to
agar surfaces, and this property increases after a few days. Nonhemolytic. Optimum
temperature is 30-37 ºC. Facultatively anaerobic. Grows poorly on nutrient agar and
doesn't grow on 5% NaCl nutrient agar.
glistening, smooth, convex surface, and 1-1.5 mm in diameter. They are adherent to
agar surfaces, and this property increases after a few days. Nonhemolytic. Optimum
temperature is 30-37 ºC. Facultatively anaerobic. Grows poorly on nutrient agar and
doesn't grow on 5% NaCl nutrient agar.
Habitat: frequently isolated from the human mouth and upper respiratory tract. Also found in bronchial secretions and blood cultures
Susceptible to ampicillin, bacitracin, chloramphenicol, erythromycin, fusidic acid, lincomycin, neomycin, novobiocin, oleandomycin,
oxytetracycline, and benzylpenicillin. Resistant to lysostaphin and lysozyme.
Susceptible to ampicillin, bacitracin, chloramphenicol, erythromycin, fusidic acid, lincomycin, neomycin, novobiocin, oleandomycin,
oxytetracycline, and benzylpenicillin. Resistant to lysostaphin and lysozyme.
May be pathogenic to humans. Rothia mucilaginosa has been reported as an opportunistic cause of meningitis leading to death in
seriously immunocompromised pediatric patients with malignant tumors or undergoing hematopoietic stem cell transplantation.
Experimental infection: subcutaneous injection of an undiluted living culture into mice produced local abscesses. Large doses may
produce fatal disease in mice. Not pathogenic for guinea pigs.
seriously immunocompromised pediatric patients with malignant tumors or undergoing hematopoietic stem cell transplantation.
Experimental infection: subcutaneous injection of an undiluted living culture into mice produced local abscesses. Large doses may
produce fatal disease in mice. Not pathogenic for guinea pigs.
- Bergan T, Kocur M. Stomatococcus mucilaginosus gen. nov., sp. nov., ep. rev., a member of the family Micrococcaceae. Int. J. Syst.
Bacteriol. 1982; 32:374-377. - Collins MD, Hutson RA, Baverud V, Falsen E. Characterization of a Rothia-like organism from a mouse: description of Rothia
nasimurium sp. nov. and reclassification of Stomatococcus mucilaginosus as Rothia mucilaginosa comb. nov. Int J Syst Evol
Microbiol 2000; 50:1247-1251. - Hans-Jurgen Busse, 2012. Family I. Micrococcaceae Pribham 1929, 361 AL emend. Stackebrandt, Rainey and Ward-Rainey 1997,
479 in: Bergey’s Manual of Systematic Bacteriology, second edition, Volume Five The Actinobacteria, Part A, Springer, 571-666. - Li Y, Kawamura Y, Fujiwara N, Naka T, Liu H, Huang X, Kobayashi K, Ezaki T. Rothia aeria sp. nov., Rhodococcus baikonurensis sp.
nov. and Arthrobacter russicus sp. nov., isolated from air in the Russian space laboratory Mir. Int J Syst Evol Microbiol 2004; 54:827-
835.
Positive results for alkaline phosphatase, esculin hydrolysis, gelatin hydrolysis, beta-glucosidase, nitrate reduction, Voges-Proskauer
test, acid production from fructose, glucose (without gas), galactose, glycerol, mannose, maltose, sucrose, salicin, and trehalose.
Negative results for arginine dihydrolase, coagulase, citrate utilization, deoxyribonuclease, egg yolk reaction, indole production, H2S
production, lysine decarboxylase, ornithine decarboxylase, oxidase, phosphatase starch hydrolysis, tyrosine, trypsin, Tween 80,
urease, acid production from adonitol, arabinose, cellobiose, dulcitol, inositol, inulin, lactose, mannitol, melibiose, raffinose,
rhamnose, ribose, sorbitol, and xylose.
Variable results for catalase (weakly positive or negative).
test, acid production from fructose, glucose (without gas), galactose, glycerol, mannose, maltose, sucrose, salicin, and trehalose.
Negative results for arginine dihydrolase, coagulase, citrate utilization, deoxyribonuclease, egg yolk reaction, indole production, H2S
production, lysine decarboxylase, ornithine decarboxylase, oxidase, phosphatase starch hydrolysis, tyrosine, trypsin, Tween 80,
urease, acid production from adonitol, arabinose, cellobiose, dulcitol, inositol, inulin, lactose, mannitol, melibiose, raffinose,
rhamnose, ribose, sorbitol, and xylose.
Variable results for catalase (weakly positive or negative).
(c) Costin Stoica
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